Thursday, July 17, 2008

Bapineuzumab in Patients With Mild to Moderate Alzheimer's Disease

This is a Phase III clinical trial and the study is currently recruiting participants.

This is a multi center, double-blind, placebo controlled, randomized, outpatient multiple dose study in male and female patients aged 50 to 89 years with mild to moderate AD. Approximately 200 study sites in the US and Canada will be involved. Patients will be randomized to receive either bapineuzumab or placebo. Each patient's participation will last approximately 1.5 years.



You can get all the specifics on this Phase III clinical trial at Clinical Trials.gov.

For a quick look at the locations participating in the study go to Locations

You can visit the Elan website to learn more about Bapineuzumab






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Wednesday, July 16, 2008

Exercise May Prevent Brain Shrinkage in Early Alzheimer's Disease


Mild Alzheimer's disease patients with higher physical fitness had larger brains compared with mild Alzheimer's patients with lower physical fitness, according to a study published in the July 15 issue of Neurology.


Physical Fitness May Slow Alzheimer's


Getting a lot of exercise may help slow brain shrinkage in people with early Alzheimer's disease, a preliminary study suggests. Analysis found that participants who were more physically fit had less brain shrinkage than less-fit participants. However, they didn't do significantly better on tests for mental performance.

That was a surprise, but maybe the study had too few patients to make an effect show up in the statistical analysis, said Dr. Jeffrey Burns, one of the study's authors.

He also stressed that the work is only a starting point for exploring whether exercise and physical fitness can slow the progression of Alzheimer's. The study can't prove an effect because the participants were evaluated only once rather than repeatedly over time, he said.

While brains shrink with normal aging, the rate is doubled in people with Alzheimer's, he said.

Burns, who directs the Alzheimer and Memory Program at the University of Kansas School of Medicine in Kansas City, reports the work with colleagues in Tuesday's issue of the journal Neurology.

The study included 57 people with early Alzheimer's. Their physical fitness was assessed by measuring their peak oxygen demand while on a treadmill, and brain shrinkage was estimated by MRI scans.

Dr. Sam Gandy, who chairs the medical and scientific advisory council of the Alzheimer's Association, said the result fits in with previous indications that things people do to protect heart health can also pay off for the brain.



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Tuesday, July 15, 2008

Portable Device Provides Quick, Inexpensive Detection of Early Alzheimer’s

This is really exciting news. A new device developed by the Georgia Institute of Technology and Emory University may allow patients to take a ten minute test that gauges reaction time and memory to measure mild cognitive impairment (MCA), often the earliest stage of Alzheimer's.

The test is inexpensive and could be administered as part of a routine yearly checkup at a doctor's office.


Watch the video at the Woodruff Health Sciences Center



Portable Device Provides Quick, Inexpensive Detection of Early Alzheimer’s


The latest medications can delay the onset of Alzheimer’s disease but none are able to reverse its devastating effects. This limitation often makes early detection the key to Alzheimer’s patients maintaining a good quality of life for as long as possible.

Now, a new device developed by the Georgia Institute of Technology and Emory University may allow patients to take a brief, inexpensive test that could be administered as part of a routine yearly checkup at a doctor’s office to detect mild cognitive impairment (MCI) — often the earliest stage of Alzheimer’s. The device is expected to be commercialized later this year.

Current assessment tests capable of detecting early Alzheimer’s typically are taken with a pen and paper or at a computer terminal and last about an hour and a half. They must be given by a trained technician in a quiet environment, because any distractions can influence the patient’s score and reduce the test’s effectiveness. Because of their length and expense, the tests are not used as regular screening tools and typically are given only after there is obvious cognitive impairment such as forgetfulness or unsafe behavior.

“Families usually wait until their mom or dad does something somewhat dangerous, like forgetting to take their medications or getting lost, before bringing them in for testing. At that point, the patient has already lost a significant portion of their cognitive function,” said David Wright, MD, who helped develop the device. Wright is assistant professor of emergency medicine in Emory University School of Medicine and co-director of the Emory Emergency Medicine Research Center. “With this device, we might be able to pick up impairment well before those serious symptoms occur and start patients on medications that could delay those symptoms.”

The Georgia Tech and Emory device, called DETECT, gives individuals a roughly ten-minute test designed to gauge reaction time and memory — functions that, when impaired, are associated with the earliest stages of Alzheimer’s disease. The test is a specially modified, shortened version of the traditional pen and paper test and could be given repeatedly by doctors to evaluate any changes in cognitive functions.

“We really envision this to be part of the normal preventative care a patient receives from a general practitioner,” said Michelle LaPlaca, Ph.D., one of the creators of the device and an associate professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University. “It would be part of a regular preventative medicine exam much like a PSA test or EKG (Electrocardiogram), serving as a cognitive impairment vital sign of sorts.”

The portable test runs patients through a battery of visual and auditory stimuli such as pictures and words that assess cognitive abilities relative to age, gauging reaction time and memory capabilities. Its software can track cognitive capabilities — and decline — year to year during annual appointments. And because the device blocks outside sound and light from the patient’s environment, it can be administered in virtually any setting, providing more consistent results.

Preliminary analysis of the first 100 patients of a 400 person clinical study being conducted at Emory’s Wesley Woods Center has shown that the 10 minute DETECT test has similar accuracy as the 90 minute ‘Gold Standard’ pen and paper test.

With millions of baby boomers easing into late adulthood, the number of patients with Alzheimer’s is expected to skyrocket over the next few decades. More than 24 million people worldwide are currently thought to have Alzheimer’s disease and by 2040, an estimated 81 million people worldwide are expected to develop the disease.

To give these millions of potential Alzheimer’s sufferers a chance to slow the disease’s advance before serious symptoms set in, doctors need an inexpensive and easy-to- administer test to detect and track the cognitive decline associated with the early stages of the disease.

The DETECT device is designed to be administered while a patient is still healthy, tracking any abnormal decreases in the patient’s cognitive performance over time. If a patient’s performance declines outside the normal range, the patient would then undergo additional testing and care from a neurologist, neuropsychologist or other specialist.

The DETECT system includes an LCD display in a visor with an onboard dedicated computer, noise reduction headphones and an input device (controller). The display projects the visual aspect of the test, the headphones provide the verbal instructions and the controller records the wearer’s response.

DETECT’s creators have formed a company, called Zenda Technologies (www.zendatech.com), to commercialize the device for MCI, as well as other conditions. Georgia Tech and Emory researchers are exploring other types of cognitive impairment such as Attention Deficit/Hyperactivity Disorder (ADHD) that could be picked up by DETECT. A version of the system designed to detect mild concussions on the sidelines of a football game, during other high-impact sports or on a battlefield, is still being tested.

The research was funded with a grant from the Wallace H. Coulter Foundation and support from the Georgia Research Alliance through Georgia Tech’s VentureLab.

Dr. Wright and Dr. LaPlaca have an equity interest in Zenda Technologies. In addition, Dr. Wright and Dr. LaPlaca are inventors on a patent application covering the DETECT technology, and may receive royalties or fees through the license agreement. Emory, Georgia Tech, Dr. Wright, and Dr. LaPlaca may benefit financially if Zenda Technologies is successful in marketing the DETECT device. Dr. Wright’s relationship with Zenda Technologies has been reviewed and approved by Emory in accordance with its policies on conflicts of interest.

For more information:
Megan McRainey
Georgia Institute of Technology
Media Relations
404-894-6016
megan.mcrainey@icpa.gatech.edu

Jennifer Johnson
Emory University, Woodruff Health Sciences Center
404-727-5696 office, 404-227-3683 cell
jennifer.johnson@emory.edu

Here is more information.

Detecting Declining Minds



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Short Mental Exercises May Slow Decline of Aging Minds

Experts said the federally funded study is a call to action for anyone who has ever worried about developing Alzheimer's, dementia and similar disorders.



Short Mental Workouts May Slow Decline of Aging Minds and Alzheimer's

Ten sessions of exercises to boost reasoning skills, memory and mental processing speed staved off mental decline in middle-aged and elderly people in the first definitive study to show that honing intellectual skills can bolster the mind in the same way that physical exercise protects and strengthens the body.

The researchers also showed that the benefits of the brain exercises extended well beyond the specific skills the volunteers learned. Older adults who did the basic exercises followed by later sessions were three times as fast as those who got only the initial sessions when it came to activities of daily living, such as reacting to a road sign, looking up a number in a telephone book or checking the ingredients on a medicine bottle -- abilities that can spell the difference between living independently and needing help.

Experts said the federally funded study is a call to action for anyone who has ever worried about developing Alzheimer's, dementia and similar disorders. Americans spend billions of dollars each year on their physical well-being, but there are no comparable efforts to keep people mentally agile and strong.

If anything, the study suggests, there is a bigger payoff to mental exercise, because the brief training sessions seemed to confer enormous benefits as many as five years later. That would be as if someone went to the gym Monday through Friday for the first two weeks of the new year, did no exercise for five years, and still saw significant physical benefits in 2012.

The researchers divided the volunteers into four groups, including a control group that received no training. A second group was trained in reasoning skills -- being asked to spot the pattern in the sequence "a, c, e, g, i," for example -- every other letter of the alphabet. A third group was taught memory skills, which involved remembering word lists and using visualizations and associations as memory aids. A fourth group was given exercises to speed up mental processing -- being asked to identify an object flashed briefly on a computer screen while fighting off distractions.

Each of the groups being trained had 10 sessions, each lasting an hour to 75 minutes, and each session presented progressively more challenging problems. Compared with the control group, those who got memory training did 75 percent better on memory tasks five years later, those who got the reasoning training did 40 percent better on reasoning tasks, and those who got the speed training did 300 percent better than the control group.

Researchers noted that mental skills can sometimes compensate for physical disabilities: Knowing how to figure out directions and find a new route on a map, for example, could allow someone to retain mobility even after their night vision deteriorates to the point where driving on certain roads becomes difficult.

The study tracked 2,802 healthy adults from diverse backgrounds who were, on average, 73 years old. Although it did not examine the effects of mental exercise on people who had begun to show signs of Alzheimer's or other brain disorders, previous studies have pointed toward the conclusion that anyone can benefit.

"People think education is for people who are already educated," said Michael Marsiske, one of the researchers. "This kind of training works no matter where you are in society."

"If you think you have come to a time in your life when new learning is impossible and there are no benefits of continuing mental activity, the study shows that for a large number of people that this is not true," added Marsiske, a clinical and health psychologist at the University of Florida at Gainesville.

The participants in the study ranged from age 65 to their early 90s, but Marsiske said the findings apply to people in their 50s or even younger. Mental skills acquired earlier in life persist well into old age, he said.

"I don't like to play my son's video games, but I keep telling myself to challenge myself," said Marsiske, 41. "What I personally take away from the study is, if you challenge yourself to do some new learning, something that isn't easy at the start, it can have dividends."

The study did not indicate that mental training can hold off all cognitive decline permanently. Rather, as is the case with physical exercise, strengthening the mind appeared to slow decline.

Sherry L. Willis, the lead author of the study and a Pennsylvania State University professor of human development, said those who had the training also reported greater confidence in their ability to solve everyday problems, and this was especially true of the group that got the reasoning training. In performing daily functions, people who got the speed training along with a handful of follow-up sessions significantly outperformed those who did not get such training.

The results, being published today in the Journal of the American Medical Association, are heartening, but Willis and Marsiske cautioned that the biggest challenge lies ahead, in getting people to apply the findings to their lives. Whether it is encouraging people to eat right or to exercise, they said, the hardest part is not getting them to start doing the right things but getting them to keep doing the right things.

"It's just like physical exercise -- when we are approaching the new year we will buy a pass for the gym and go fervently in January and then slack off," Willis said. "Mental exercise is the same way. It has to be consistent, and it has to be challenging. Just like you have to keep increasing the weights at the gym to make it challenging, you have to do the same with mental activity."

To reap the benefits, Willis said, people need to get outside their comfort zones. For someone who likes to solve crossword puzzles, it is important to make sure the puzzles get harder with time -- or to start playing chess. Someone who hates to play games, she said, should find something else that stretches the mind. Mental activities do not have to involve expensive toys; everyday life can offer a variety of mental challenges. Finding a friend who can join in a new activity can be a powerful motivator, she added.

Sally Shumaker, a professor of public health science at Wake Forest University in North Carolina who wrote an editorial accompanying the study, said it pointed the way to a future in which mental training is made widely available.

"I can imagine a situation in which facilities are available in community centers and libraries and aging centers, where people can play some games that are specifically designed to improve cognitive ability," she said. "People are fearful of cognitive decline, and the idea that a small and simple intervention can have an impact is pretty compelling."




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My mother--Exercise may slow Alzheimer's brain atrophy

When my mother first showed signs of dementia she was falling down almost daily. Then she fell and broke her finger. My mother who a year earlier could walk 15 blocks without any real problem could no longer walk a block. I knew I had to do something. While I was trying to decide what to do her health care provider (Humana) began offering a free membership to a health club (Gold's Gym). I enrolled her in Gold's and the Silver Sneakers program. She stopped falling. Once I realized that it was her brain and not her ability to walk, I started putting her on the treadmill. Four years later my mother is walking very slow and holding my hand very tight when she walks. Her brain is sending her all kinds of false messages. Here is the good news, she has not fallen once in these four years. An amazing result for a 92 year old woman suffering from Alzheimer's disease.

As some of you know, I am a big proponent of exercise and I believe this is a necessary component of staving off the dreaded effects of Alzheimer's.



Exercise may slow Alzheimer's brain atrophy

Getting a lot of exercise may help slow brain shrinkage in people with early Alzheimer’s disease, a preliminary study suggests.

Analysis found that participants who were more physically fit had less brain shrinkage than less-fit participants. However, they didn’t do significantly better on tests for mental performance.

That was a surprise, but maybe the study had too few patients to make an effect show up in the statistical analysis, said Dr. Jeffrey Burns, one of the study’s authors.

He also stressed that the work is only a starting point for exploring whether exercise and physical fitness can slow the progression of Alzheimer’s. The study can’t prove an effect because the participants were evaluated only once rather than repeatedly over time, he said.

While brains shrink with normal aging, the rate is doubled in people with Alzheimer’s, he said.

Burns, who directs the Alzheimer and Memory Program at the University of Kansas School of Medicine in Kansas City, reports the work with colleagues in Tuesday’s issue of the journal Neurology.

The study included 57 people with early Alzheimer’s. Their physical fitness was assessed by measuring their peak oxygen demand while on a treadmill, and brain shrinkage was estimated by MRI scans.

Dr. Sam Gandy, who chairs the medical and scientific advisory council of the Alzheimer’s Association, said the result fits in with previous indications that things people do to protect heart health can also pay off for the brain.

URL: http://www.msnbc.msn.com/id/25676632/



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Sunday, July 13, 2008

Detection and Diagnosis of Alzheimer's Disease

Dr. Dean Reports: "As the numbers grow so does the likelihood you will face Alzheimer's in your life. Discover what researchers are learning about this mind robbing condition."






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Thursday, July 10, 2008

Do Brain Games Helps?

There is a lot of controversy around brain games. Skeptics say, no they don't really help. Others believe they are of enormous help in keeping the brain sharp or helping those with Alzheimer's.

My mother plays Slingo on the computer. I believe it helps. If nothing else it keeps her brain active and I am always looking for ways to keep her brain working.

One thing for sure, it can't hurt. So I recommend games like Slingo.

Good article, read on....
clipped from abcnews.go.com


"I was having memory problems just like everyone else has at my age," Goldberg explained. "Using these games has given me a dramatic improvement in my memory. I'm able to recall names, places and companies that I couldn't remember in the past. And it surprises me I can remember these things and it's given me much greater confidence."

 blog it

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